Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints
- 1 October 1993
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 92 (3) , 305-308
- https://doi.org/10.1007/bf00244478
Abstract
A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X; 1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.Keywords
This publication has 18 references indexed in Scilit:
- Assignment of three human high-affinity Fcγ receptor I genes to chromosome 1, band q21.1Immunogenetics, 1993
- Translocation (X;1) in papillary renal cell carcinoma a new cytogenetic subtypeCancer Genetics and Cytogenetics, 1993
- Generation and characterization of radiation reduced cell hybrids and isolation of probes from the proximal short arm of the human X chromosomeHuman Genetics, 1992
- Physical mapping of 60 DNA markers in the p21.1 → q21.3 region of the human X chromosomeGenomics, 1991
- Leukemia and the disruption of normal hematopoiesisCell, 1991
- Involvement of chromosome X in primary cytogenetic change in human neoplasia: nonrandom translocation in synovial sarcoma.Proceedings of the National Academy of Sciences, 1987
- Regional localisation of X chromosome short arm probesHuman Genetics, 1986
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1984
- TOWARD A COMPLETE LINKAGE MAP OF THE HUMAN CHROMOSOME-X - REGIONAL ASSIGNMENT OF 16 CLONED SINGLE-COPY DNA-SEQUENCES EMPLOYING A PANEL OF SOMATIC-CELL HYBRIDS1984
- Expression of human myeloid-associated surface antigens in human-mouse myeloid cell hybrids.Proceedings of the National Academy of Sciences, 1983