Inhibition of Prostaglandin Biosynthesis by Tolfenamic Acid in Vitro
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 5 (3) , 129-132
- https://doi.org/10.3109/03009747609165450
Abstract
The effect of tolfenamic acid on prostaglandin biosynthesis was investigated by using rabbit kidney medulla microsomal fraction, and the results compared with those obtained with indomethacin and acetylsalicylic acid. Tolfenamic acid inhibited the conversion of arachidonic acid to prostaglandin E2 very effectively and in a dose-dependent manner. IC50 values were 0.64 μM for tolfenamic acid, 0.76 μM for indomethacin, and 7 mM for acetylsalicylic acid. The inhibition of prostaglandin biosynthesis may be related to the good anti-inflammatory action of tolfenamic acid.This publication has 10 references indexed in Scilit:
- A sensitive biological assay for prostaglandin E and acetylcholineJournal of Pharmacy and Pharmacology, 1976
- New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory DrugsAnnual Review of Pharmacology, 1974
- INHIBITION OF THE PROSTAGLANDIN SYNTHETASE SYSTEMS IN OCULAR TISSUES BY INDOMETHACINBritish Journal of Pharmacology, 1974
- The use of the hamster stomach in vitro as an assay preparation for prostaglandinsBritish Journal of Pharmacology, 1973
- Effects of Anti-inflammatory Drugs on Prostaglandin BiosynthesisNature New Biology, 1972
- Effect of Tolfenamic Acid in Rheumatoid ArthritisScandinavian Journal of Rheumatology, 1972
- Indomethacin and Aspirin abolish Prostaglandin Release from the SpleenNature New Biology, 1971
- Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like DrugsNature New Biology, 1971
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951