The chemistry of penicillanic acids. Part I. 6,6-Dibromo- and 6,6-di-iodo-derivatives
- 1 January 1969
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- No. 16,p. 2123-2127
- https://doi.org/10.1039/j39690002123
Abstract
6,6-Dibromopenicillanic acid (IIIa) and 6,6-di-iodopenicillanic acid (IIIc) have been observed in the products of the deamination of 6β-aminopenicillanic acid (Ia) in the presence of sodium bromide and sodium iodide respectively. Deamination of (Ia) in the presence of bromine has resulted in the isolation of 6,6-dibromopenicillanic acid (IIIa) in 35% yield. The 1β-(Va) and 1α-(VIa) sulphoxides of this acid are described, together with some of its properties.Keywords
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