Canine Parvovirus: Relationship to Wild-type and Vaccine Strains of Feline Panleukopenia Virus and Mink Enteritis Virus

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Abstract
Canine parvovirus (CPV), feline panleukopenia virus (FPLV) and mink enteritis virus (MEV) were compared serologically, by determination of their host range in cell cultures and by restriction enzyme analysis. Maps of the virus genomes were established using 7 different restriction enzymes cutting at a total of 56 sites. MEV and FPLV gave maps which were identical except for 1 restriction site. The map of CPV is closely related to those of FPLV/MEV since their DNA share .apprx. 80% of the restriction sites tested. CPV is clearly distinct from FPLV/MEV since either 8 (German isolate) or 9 (Belgian, Swiss and American isolates) restriction sites are different. The DNA of 6 vaccine strains of FPLV and MEV were also analyzed. They gave maps which closely resembled those of the respective wild-type strains. CPV and FPLV/MEV also differed with respect to antigenicity and host range in cell cultures.

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