L-Dopa: Effect on Concentrations of Dopamine, Norepinephrine, and Serotonin in Brains of Mice

15 May 1970

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 168 (3933) , 849-850
https://doi.org/10.1126/science.168.3933.849

Abstract

Large doses of L-dopa given to mice produced marked increases in brain dopamine, no change in norepinephrine, and a remarkable decrease in brain serotonin. This reduction apparently results from a release or displacement, or both, of serotonin from its storage sites.

Keywords

SEROTONIN
NOREPINEPHRINE
REMARKABLE
CONCENTRATIONS OF DOPAMINE
EFFECT ON CONCENTRATIONS
BRAIN
MARKED INCREASES
REDUCTION APPARENTLY

This publication has 2 references indexed in Scilit:

Treatment of Parkinsonism With Levodopa
Archives of Neurology, 1969
Modification of Parkinsonism — Chronic Treatment with L-Dopa
New England Journal of Medicine, 1969