ABNORMAL LIPOPROTEIN APPEARING IN PLASMA OF PATIENTS WHO RECEIVED A 10-PERCENT SOYBEAN OIL EMULSION INFUSION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 85  (5) , 566-574
Abstract
In 42 and 43 surgical patients who received a 10% soybean oil emulsion (Intralipid), abnormal lipoprotein was detected in their plasma 1-2 days after the initial Intralipid infusion. This abnormal lipoprotein was proven to appear as a result of the infusion of soybean oil emulsion regardless of the patient''s original diseases, age, sex, liver function, or concomitantly administered solutions. This abnormal lipoprotein was found to have various similarities to lipoprotein-X (LP-X) which is found in plasma from patients with obstructive jaundice or familial lecithin:cholesterol acyltransferase deficiency. This abnormal lipoprotein was tentatively named LP-X-like substance (LP-X-LS). A comparison of the properties of LP-X and LP-X-LS was performed and the following results were obtained: LP-X-LS migrated toward the cathode on Bacto-Agar gel electrophoresis similarly to LP-X; the stability of LP-X and LP-X-LS against heating and freezing were almost equal under various conditions; LP-X-LS could be absorbed by anti-LP-X serum; LP-X-LS existed in low density fraction (d (density) = 1.063) separated by ultracentrifugation from plasma; EM study of low-density lipoprotein particles from LP-X-LS positive plasma revealed that LP-X-LS had a similar ultrastructure to LP-X. LP-X-LS is apparently an abnormal lipoprotein quite similar to LP-X.

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