Abstract
The conc. of histidine in serum proteins and protein-free blood filtrates was detd. by Pauly''s color reaction with diazobenzo-sulfonic acid after the intraven. inj. of l-3 g. of l- or d-histidine into rabbits and a human subject. In all cases the conc. of histidine in the serum proteins was greater after l- than after d-histidine; the reverse was true for the protein-free filtrate. The natural l form may have been the more readily incorporated into the serum proteins, the unnatural d form may have undergone partial conversion into the l form, or may have been more rapidly metabolized. The metabolism was more rapid in the human.

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