Adoptive immunochemotherapy of a transplantable AKR leukemia (K36)

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Abstract
Adoptive immunotherapy of a transplantable AKR leukemia (K36) was carried out as an adjunct to cytoxan chemotherapy using normal allogeneic H‐2‐incompatible spleen cells as well as sensitized H‐2‐matched allogeneic spleen cells. A significant therapeutic effect was obtained with cytoxan and allogeneic C57BL/6 splenocytes, demonstrating the potential use of the graft‐versus‐host reaction. Utilizing specific adoptive immunochemotherapy, a maximum effect was found with splenocytes from allogeneic but H‐2‐compatible CBA/J mice immunized against an allogeneic Gross‐virus‐induced lymphoma (EoG2). This therapeutic effect was most likely the result of prior sensitization of donor lymphocytes to common virus‐associated tumor antigens.