One-pot Synthesis of Optically Active Tetramic Acids from Amino Acids Mediated by 1-Hydroxybenzotriazole
- 27 September 2001
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2001 (10) , 1653-1655
- https://doi.org/10.1055/s-2001-17452
Abstract
A novel synthesis of chiral 3-ethoxycarbonyl-5-substituted tetramic acids in moderate yields (45-75%) is reported. HPLC analysis of these tetramic acids shows very good enantiomeric excesses (82-98%).Keywords
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