Spontaneous Autoimmunity in Mice: Antibodies to Nucleoprotein in Strain A/J
- 20 March 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 143 (3612) , 1333-1334
- https://doi.org/10.1126/science.143.3612.1333
Abstract
An antibody to nucleoprotein, which appears to be an autoantibody, occurs in the γ-globulin fraction of serum from mice of the A/J strain. This antibody combines with nucleoprotein of several species but not with calf thymus DNA. The frequency of its occurrence increases with age and is greater in females. Serums that contain the antibody produce typical lupus erythematosus cells in vitro.Keywords
This publication has 3 references indexed in Scilit:
- The Natural History of Autoimmune Disease in NZB MiceAnnals of Internal Medicine, 1963
- SPECIFIC NUCLEAR REACTION PATTERN OF ANTIBODY TO DNA IN LUPUS ERYTHEMATOSUS SERA1963
- Clinical diagnosis of systemic lupus erythematosusThe American Journal of Medicine, 1958