Lipidg Peroxidation in Liver and Ehrlich Ascites Cell Mitochondria
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 7 (3-6) , 161-170
- https://doi.org/10.3109/10715768909087938
Abstract
Ehrlich ascites cell mitochondria are highly resistant to lipid peroxidation as compared to liver mitochondria from host animals. Succinate protects mitochondria from peroxidative damage, proteins from crosslinks, enzymes from inactivation of the enzymes and membranes from permeability changes. The sensitivity of Ehrlich ascites cell mitochondrial membranes to lipid peroxidation is significantly increased in sub-mitochondrial particles. Lipid peroxidation in tumour mitochondrial membranes can not be diminished by succinate as effectively as in liver mitochondria. Ascites cell mitochondria seems to be protected very efficiently from peroxidative damage by a glutathione-dependent mechanism.Keywords
This publication has 28 references indexed in Scilit:
- Lipid peroxidation in regenerating rat liverFEBS Letters, 1986
- Comparison of cumene hydroperoxide- and NADPH/Fe3+/ADP-induced lipid peroxidation in heart and liver submitochondrial particlesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984
- Mitochondrial substrate oxidation-dependent protection against lipid peroxidationBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
- Superoxide dismutase content and microsomal lipid composition of tumours with different growth ratesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
- Membrane-bound glutathione peroxidase-like activity in mitochondriaBiochemical and Biophysical Research Communications, 1980
- Growth-related lipid peroxidation in tumour microsomal membranes and mitochondriaBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
- Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH‐S‐transferasesFEBS Letters, 1979
- Age-dependent changes in rat liver microsomal and mitochondrial NADPH-dependent lipid peroxidationBiochemical and Biophysical Research Communications, 1977
- Superoxide dismutase and glutathione peroxidase activities in tumorsFEBS Letters, 1977
- Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functionsBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1973