A Double-Blind Trial of Amitriptyline/Perphenazine, Perphenazine and Placebo in Chronic Withdrawn Inert Schizophrenics

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Abstract
Since the introduction of chlorpromazine in the early 1950's, various phenothiazine tranquillizers have become established as standard treatment in schizophrenia. However, it is recognized that these drugs have their limitations; every mental hospital contains a large group of schizophrenics whose illness is unaffected or only partially modified by phenothiazines, and some patients develop side-effects sufficiently severe to preclude these drugs being given in fully effective doses.