Synthesis in the diazasteroid group. XVIII. Syntheses of the 9,17-diazasteroid system.
- 1 January 1982
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (4) , 1300-1306
- https://doi.org/10.1248/cpb.30.1300
Abstract
A 9, 17-diazasteroid system, I, was synthesized from an aminoester, III, and cyclohexanone. Unfortunately the yield was poor. Another 9, 17-diazasteroid system, II, was prepared from the condensation product, XVa, of quinoline N-oxide with an active methine compound, IV. Thus, XVa was hydrolyzed, followed by decarboxylation, reduction and cyclization. The yield in each step to II was moderate.Keywords
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