MK-801 Reduces Extensive Infarction after Suture Middle Cerebral Artery Occlusion in Rats

Publisher Website
Google Scholar
Abstract
We examined neurological deficits and infarct volumes, as determined by 2,3,5-triphenyltetrazolium chloride staining, 24 h after intraluminal suture occlusion of the middle cerebral artery (MCA) in 2 groups of 10 male Sprague-Dawley rats treated after the onset of ischemia with the noncompetitive N-methyl-D-aspartate antagonist, dizocilpine maleate (MK-801) or saline. Although MK-801 caused a significant drop in blood pressure, it significantly improved the neurological status 24 h after MCA occlusion (p 3 in the control and 157 ± 46 in the MK-801-treated group (mean ± SEM, p

This publication has 0 references indexed in Scilit: