The Preleukemic Syndrome: Clinical and Laboratory Features, Natural Course, and Management

Publisher Website
Google Scholar
Abstract
The clinical and laboratory features of the early stages in the evolution of acute nonlymphocytic leukemia are reviewed. Based on a retrospective analysis of 34 patients who died with an acute myelomonoblastic leukemia, the “preleukemic syndrome” has been shown to display a clinical picture sufficiently specific to permit its recognition prospectively (i.e., before the development of overt leukemia). The results to date of a variety of prospective studies are reviewed, and the approach(es) to the management of these cases is considered.