The effect of ciprofibrate on gastric secretion in the rat

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Abstract
The potential of ciprofibrate to inhibit gastric secretion has been investigated in the rat. A significant gastric antisecretory effect was observed following a single oral administration of 300 and 500 mg kg−1 and following a single intraduodenal dose of 100, 300 and 500 mg kg−1. The toxicological significance of this finding is discussed in the light of a spate of recent publications linking changes in gastric morphology with hypergastrinaemia produced as a secondary effect of inhibition of acid secretion.