Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis
- 1 October 1999
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 53 (6) , 1361
- https://doi.org/10.1212/wnl.53.6.1361
Abstract
Article abstract The associations of three promoter polymorphisms in the tumor necrosis factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and theTNFA-376 polymorphism. This association was independent of the human leukocyte antigen (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the TNFA-376A allele more than additively increased susceptibility to MS.Keywords
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