Ascorbate Autoxidation in the Presence of Iron and Copper Chelates
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 1 (6) , 349-353
- https://doi.org/10.3109/10715768609051638
Abstract
Chelates can inhibit the iron- and copper-catalyzed autoxidation of ascorbate at pH 7.0. Diethylenetri-aminepentaacetic acid (DTPA or DETAPAC) and Desferal (deferoximane mesylate) slow the iron-catalyzed oxidation of ascorbate as effectively as reducing the trace levels of contaminating iron in buffers with Chelex resin. DETAPAC, EDTA and HEDTA (N-(2-hydroxyethyl)-ethylenediaminetriacetic acid) are effective at slowing the copper-catalyzed autoxidation of ascorbate while Desferal is ineffective. The ability to inhibit ascorbate autoxidation appears to parallel the rate of the reaction of superoxide with the iron chelate.Keywords
This publication has 25 references indexed in Scilit:
- Formation of mutagens in cooked foods. VI. Modulation of mutagen formation by iron and ethylenediaminetetracetic acid (EDTA) in fried beefCancer Letters, 1984
- Chelates of Ascorbic AcidPublished by American Chemical Society (ACS) ,1982
- Ethylene from 2-keto-4-thiomethyl butyric acid: The Haber-Weiss reactionArchives of Biochemistry and Biophysics, 1980
- Superoxide anions do not react with hydroperoxidesFEBS Letters, 1979
- Influence of heme pigments, nitrite, and nonheme iron on development of warmed-over flavor (WOF) in cooked meatJournal of Agricultural and Food Chemistry, 1979
- THE EFFECT OF IRON ON THE DISTRIBUTION OF SUPEROXIDE AND HYDROXYL RADICALS AS SEEN BY SPIN TRAPPING AND ON THE SUPEROXIDE DISMUTASE ASSAYPhotochemistry and Photobiology, 1978
- Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelatesFEBS Letters, 1978
- Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complexFEBS Letters, 1978
- Complexes of doubly chelating ligands. Part I. Proton and copper(II) complexes ofL-β-(3,4-dihydroxyphenyl)alanine (DOPA)J. Chem. Soc. A, 1968
- Metal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. I. Cupric and ferric ion catalyzed oxidationJournal of the American Chemical Society, 1967