In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+
- 1 February 1992
- journal article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 89 (1-2) , 139-145
- https://doi.org/10.1007/bf01245361
Abstract
Increased formation of hydroxyl free radicals (·OH) reflected by ·OH adduct of salicylate in brain dialysate was demonstrated during the sustained (more than 2 hours) dopamine overflow elicited by 75 nmol of 1-methyl-4-phenyldihydropyridine (MPDP+) and 1-methyl-4-phenylpyridinium (MPP+) in the rat striatum. Owing to its weak dopamine releasing action, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) did not significantly increase the ·OH formation. This data suggests that sustained elevation of dopamine in the extracellular fluid elicited by MPTP analogues can be auto-oxidized, which in turn leads (possibly by indirect mechanisms) to the formation of cytotoxic ·OH free radicals near the nigrostriatal terminals.Keywords
This publication has 37 references indexed in Scilit:
- Enhanced hydroxyl radical generation by 2′‐methyl analog of MPTP: Suppression by clorgyline and deprenylSynapse, 1992
- 21‐Aminosteroids Interact with the Dopamine Transporter to Protect Against 1‐Methyl‐4‐Phenylpyridinium‐Induced NeurotoxicityJournal of Neurochemistry, 1992
- Hydroxylation of salicylate as an assay for hydroxyl radicals: A cautionary noteFree Radical Biology & Medicine, 1991
- Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray MicroanalysisJournal of Neurochemistry, 1991
- 1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particlesBiochemical and Biophysical Research Communications, 1990
- In Vivo Autoxidation of Dopamine in Guinea Pig Striatum Increases with AgeJournal of Neurochemistry, 1990
- Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP+Journal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1988
- Formation of superoxide and hydroxyl radicals from 1-methyl-4-phenylpyridinium ion(MPP+): Reductive activation by NADPH cytochrome P-450 reductaseBiochemical and Biophysical Research Communications, 1986
- The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metalsBiochemical and Biophysical Research Communications, 1985
- Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine Levels in human basal gangliaJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1976