INHIBITION OF DNA-SYNTHESIS BY RETINYL ACETATE DURING CHEMICALLY-INDUCED MAMMARY CARCINOGENESIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (4) , 1109-1111
Abstract
The effect of retinoids on DNA synthesis was studied in the female Sprague-Dawley rat. Animals were treated with solvent, 7,12-dimethylbenz(a)anthracene or 1-methyl-1-nitrosourea at 50 days of age and were placed on placebo or retinyl acetate diet at 57 days of age. [3H]thymidine incorporation into purified DNA isolated from mammary parenchymal cells was determined. Retinyl acetate effectively inhibited mammary cell DNA synthesis in 1-methyl-1-nitrosourea- and 7,12-dimethylbenz(a)anthracene-treated animals; DNA synthesis in solvent-treated animals was unaffected.

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