DNA Haplotypes and Frameworks Associated with the Beta-Globin Gene in the Kachari Population of Assam (India)

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Abstract
DNA haplotypes and frameworks associated with the .beta.-globin gene were determined in a Tibeto-Burman group, the Kachari, from Upper Assam, India, using restriction analysis at eight restriction sites. Of the total of 59 subjects, 26 were homozygous for HBB*A and 33 homozygous for HBB*E. Complete heplotype determination in 33 subjects revealed a conspicuous difference in haplotype distribution between HBB*A- and HBB*E-bearing chromosomes. The Southeast Asian HBB*E-associated haplotype-+-+++ +-(27-2 in the present terminology) predominated on HBB*E chromosomes. The previously established .beta.-globin-associated frameworks 1, 2 and 3 were evenly distributed among the HBB*A chromosomes, whereas all HBB*E chromosomes had framework 2. These findings favor a common origin of the HBB*E gene in Southeast Asia and Assam.

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