Periodicity and Hypsarrhythmia in the EEG

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Abstract
Introduction In 1956 and 1958 Lesse, Hoefer, and Austin1,2 reported on clinical and electroencephalographic (EEG) findings in 11 patients suffering from a variety of diffuse encephalopathies of different etiologies and clinical outcome, but with a common EEG abnormality, namely, periodic synchronous bursts of irregular slow and spike-and-wave activity, mainly of high amplitude and with depression of activity in the interval. It was our impression that the EEG pattern was related to a profound cerebral, chiefly cortical, disturbance. The clinical features of this disturbance are: organic mental changes, myoclonic and generalized convulsions, rigidity, and a choreo-athetoid form of dyskinesia. Earlier authors3,4 had considered the EEG pattern to be specific for subacute sclerosing leukoencephalitis of the Dawson5 and van Bogaert6 varieties. Only one of our own original cases fell into this category, and we concluded that the clinical picture was indicative of a state of physiological impairment with

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