Synthesis of Some 4-Chloro-5-cyano-2-dialkylamino-6H-1,3-oxazin-6-ones and their Reactions with Trialkyl Phosphites to Give Dialkyl (5-Cyano-2-dialkylamino-6-oxo-6H-1,3-oxazin-4-yl)phosphonates
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (05) , 443-446
- https://doi.org/10.1055/s-1992-26129
Abstract
The reaction of the salts of alkyl dicyanoacetates and N-(dichloromethylene) dialkylammonium chlorides in chloroform leads to 4-chloro-5-cyano-2-dialkylamino-6H -1,3-oxazin-6-ones. The chloro atom of these compounds can be easily substituted in a Michaelis-Arbuzov reaction with trialkyl phosphites, giving dialkyl (5-cyano-2-dialkylamino-6-oxo-6-H-1,3-oxazin-4-yl)phosphonates in good yields.Keywords
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