Steroid-Sensitive Single Neurons in Rat Hypothalamus and Midbrain: Identification by Microelectrophoresis
- 5 May 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3775) , 667-669
- https://doi.org/10.1126/science.156.3775.667
Abstract
Minute amounts of Na-dexamethasone-21-phosphate administered by microelectrophoresis to the immediate extracellular environment promptly suppressed electrical activity of 15 out of 115 hypothalamic and mesencephalic neurons, the effect being readily reversible. Such neurons marked with fast green were found to lie in circumscribed areas of the periventricular gray of the third ventricle and aqueduct, and may represent a site of action of adrenocortical steroids in the regulation of corticotrophin releasing factor and/or adrenocortico-tropin secretion by negative feedback.Keywords
This publication has 14 references indexed in Scilit:
- ELECTROPHYSIOLOGICAL STUDIES ON THE HYPOTHALAMUSBritish Medical Bulletin, 1966
- Effect of Hypothalamic and Mesencephalic Steroid Implantations on ACTH Feedback Mechanisms1Endocrinology, 1965
- Studien über Angiotensin IIJournal of Vascular Research, 1964
- Diffuse Hypothalamic System for the Regulation of ACTH Secretion1Endocrinology, 1963
- Effects of intrahypothalamic crystalline steroids on acute ACTH secretionAmerican Journal of Physiology-Legacy Content, 1963
- Cerebral Involvement in the Inhibition of ACTH Secretion by HydrocortisoneEndocrinology, 1963
- EFFECTS OF IMPLANTATION OF CORTISOL INTO THE BRAIN STEM OR PITUITARY GLAND ON THE ADRENAL RESPONSE TO STRESS IN THE RABBITActa Endocrinologica, 1962
- FUNCTIONAL AND MORPHOLOGICAL OBSERVATIONS ON THE RAT PITUITARY GRAFTED INTO THE ANTERIOR CHAMBER OF THE EYEJournal of Endocrinology, 1959
- Localization of brain-stem lesions inhibiting compensatory adrenal hypertrophy following unilateral adrenalectomyCell and tissue research, 1959
- THE RAPIDITY OF THE ADRENOCORTICOTROPIC RESPONSE OF THE PITUITARY TO THE INTRAVENOUS ADMINISTRATION OF HISTAMINE123Endocrinology, 1951