Cardiovascular Effects of Chloroquine with Special Reference to Its Antifibrillatory Action

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Abstract
Intravenous injections of chloroquine terminated experimental atrial fibrillation in open chest dog preparations. Chloroquine and quinidine possess equal vasodilating properties when injected intra-arterially in the same dosage. Chloroquine and quinidine were equally effective in decreasing resting excitability of isolated cat papillary muscle; conduction velocity was markedly slowed by quinidine, but only slightly decreased by chloroquine.