Early ductal lesions of pancreatic carcinogenesis in animals and humans

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Abstract
Summary Two cases of human early pancreatic duct adenocarcinoma were presented, and ductal lesions observed histologically were compared to those induced in hamsters using a rapid-production model of pancreatic carcinoma. In human cases, direct histologic evidence was obtained to suggest that cancerous changes arose from duct epithelial cell hyperplasia, because lesions of hyperplasia and carcinoma coexisted in continuity. In hamster serialkilling studies, it was suggested that carcinoma developed through atypical ductal hyperplasia.