Allotype suppression in the chicken II. Suppression in homozygous chickens with antiallotype antibody and allotype‐disparate B cells

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Abstract
Injection of heterozygous (M‐13/M‐1b, G‐1g/G‐1i) B 14‐line chickens with antisera directed against either IgM‐1a or IgM‐1b induced suppression of the relevant IgM‐1 and genetically linked IgG‐1 allotypes, whereas a mixture of anti‐M‐1a and anti‐M‐1b antibodies failed to produce allotype suppression. Injection of anti‐M‐1 antiserum into M‐1 homozygous chickens induced only a transient delay of a few days in the appearance and rise of serum IgM‐1 levels. However, suppression of host allotypes was induced by injecting M‐1, G‐1 homozygous neonatal or embryonal recipients with anti‐M‐1 antisera together with B locus‐histocompatible allotype‐disparate spleen, bone marrow or bursal cells. The active cell type were donor B cells, which established chimerism in the injected hosts, whereas peripheral blood T lymphocytes from agammaglobulinemic donors were ineffective. Allotype suppression was attributed to a homeostatic control mechanism which is exerted by normal B cells (but not T cells) over B cell recruitment in anti‐M‐1 antibody‐treated, immature hosts.