New Models for the Mesophases of Disodium Cromoglycate (INTAL)
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Molecular Crystals and Liquid Crystals
- Vol. 64 (1) , 19-24
- https://doi.org/10.1080/01406568008072650
Abstract
New models are proposed for the two lyotropic liquid crystal phases of the anti-asthmatic drug, disodium cromoglycate (DSCG). It is suggested that the M phase consists of square hollow cylinders of DSCG packed in a hexagonal array in a water continuum. Each hollow cylinder consists of a stack of rings of four DSCG molecules and is filled with water. The N phase, which occurs at higher dilution, is pictured as a nematic array of the same hollow cylinders but separated by so much water that although the local parallelism is retained, the hexagonal ordering is lost.Keywords
This publication has 3 references indexed in Scilit:
- X-ray analysis of disodium cromoglycateJournal of Pharmacy and Pharmacology, 1974
- Mesomorphism in the System Disodium Chromoglycate-WaterMolecular Crystals and Liquid Crystals, 1973
- Solid-State Chemistry of Cromolyn Sodium (Disodium Cromoglycate)Journal of Pharmaceutical Sciences, 1971