Effects of Adrenal Steroids and Thyroid Hormone on Creatine and Kidney Trans amidinase in the Rat

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Abstract
The role of the adrenal steroid hormones and the thyroid hormones in the regulation of rat kidney transamidinase has been investigated. Adrenalectomy or thy-roidectomy had no apparent effect on the enzyme. Kidneys from rats that had received excessive doses of thyroid or adrenal steroid hormones had low kidney transamidinase activities. There was a good correlation between the low transamidinase activities and the high levels of creatine in the blood and kidneys of the cortisol and triiodo-thyronine injected rats. It is suggested that increased creatine levels may be responsible for the low transamidinase activities found in rats given large doses of adrenal steroid or thyroid hormones.

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