A haemodynamic and pharmacokinetic study to assess a new transdermal nitroglycerin preparation in normal subjects

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Abstract
A continual application of a transdermal Nitroglycerin (Nitrodur) has been haemodynamically and pharmacokinetically assessed in a group of 10 normal healthy volunteers over a 24 h period. There were significant decreases in left ventricular end systolic dimension and end diastolic dimension over this period, demonstrating a continuous haemodynamic effect. A dose related response was not demonstrated, although low plasma nitroglycerin levels produced significant haemodynamic changes. The persistant decrease in left ventricular wall stress implies a reduction in myocardial oxygen consumption. Thus Nitrodur may play an important role in the long term prophylaxis of angina.