SUPPRESSION OF IMMUNOLOGICAL RESPONSES IN MICE BY TREATMENT WITH AMPHOTERICIN-B

  • 1 January 1979
    • journal article
    • research article
    • Vol. 38  (1) , 70-76
Abstract
The polyene antibiotic amphotericin B (AmB) caused a marked suppression of the cell-mediated immune response in mice. Similar treatment did not affect the humoral antibody response. The immunosuppressive property of the drug was related to its ability to inhibit manifestation rather than the induction phase of the delayed-type hypersensitivity response. In vitro AmB suppressed mitogen-induced lymphocyte proliferation. The drug seemed to act at the proliferative phase of the response. The T [thymus-derived] cell response was much more sensitive to AmB action than was the B [bone marrow-derived] cell response. During AmB chemotherapy consideration must be given to immunosuppressive properties of this drug.