AN OBSESSIVE-COMPULSIVE REACTION TREATED WITH PREFRONTAL PROCAINE INJECTION
- 14 November 1953
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 153 (11) , 1015-1016
- https://doi.org/10.1001/jama.1953.02940280023007
Abstract
Injection of various substances into the frontal lobe of the brain has been one of the various methods utilized to treat intractable pain and certain psychiatric disorders since Moniz's original report on lobotomy in 1936.1 He injected small amounts of alcohol in some of his early cases. Lindsay,2 in 1950, described the injection of small amounts of procaine into the forebrain of three psychotic patients. Putnam3 and Van Wagenen4 have used procaine injections as a preliminary and temporary procedure in an effort to estimate in advance the possible effect of a surgical prefrontal lobotomy. Two of us (F. E. N. and F. C. G.)5 have used multiple injections of much larger amounts of procaine for the relief of intractable pains from advanced carcinoma. This idea followed John Adams'6 demonstration in San Francisco in 1950 that long-term changes in psychotic behavior resulted from massive frontalKeywords
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