Buckley’s Syndrome and Membranoproliferative Glomerulonephritis

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Abstract
A 30-year-old patient with chronic atopic eczema, recurrent sinusitis and membranoproliferative type I glomerulonephritis (MPGN) is presented. Features of the Buckley hyper-IgE syndrome were present with permanent, very high levels of serum IgE ( > 10,000 IU/ml) and abnormal granulocyte chemotaxis. Bouts of sinusitis, eczema and enhanced proteinuria occurred simultaneously several times. The relations between an immune deficiency and the occurrence of MPGN are discussed.