Abstract
Substitution of a CO-group in C5H5Mn(CO)3 by a donator (D) decreases the toxicity whereas with Cr(CO)6 it is increased by aliphatic amines and anilin. This effect is greatest with piperidine as the ligand and decreases by way of the aliphatic and aromatic nitrogen bases. For the same ligands the toxicity of Cr(CO)5D compounds is always greater than that of the corresponding C5H5Mn(CO)2D derivatives. Substitution of a hydrogen in the cyclopentadienyl ring by a CH3 group reduces the toxicity.

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