STUDIES ON SERUM PROTEOLYTIC ENZYME INHIBITION

Open Access
Publisher Website
Google Scholar
Abstract
Serial studies of the serum proteolytic enzyme inhibitor in monkeys show prompt elevation of the inhibitor following inflammation produced by injections of turpentine-Falba. Similar response follows daily administration of cortisone acetate in doses of 25 mg/kg body weight. Premedication of animals with cortisone appears to inhibit the response of the inhibitor to the turpentine-Falba abscess. Response to cortisone administration is not inhibited by removal of the spleen. Total body irradiation, thermal injury, and the administration of egg albumin elicited only slight changes in the serum enzyme inhibitor despite evidence of tissue destruction. The correlation of these findings to the mechanism of inflammation is discussed.