GLYCOSAMINOGLYCANPOLYSULPHATE (GAGPS, ARTEPARON) IN TREATMENT OF OSTEOARTHROSIS .3. BIOCHEMICAL CLINICAL INVESTIGATION OF EFFECT OF INTRAMUSCULAR GAGPS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 36  (7-8) , 269-274
Abstract
Investigations using 3H-Arteparon showed that in humans with degenerative joint disease an i.m. administration of 125 mg GAGPS (0.5 ml Arteparon forte) produced GAGPS concentrations within the joint, which in a biochemical assay inhibited cartilage degrading lysosomal enzymes. The dosage was determined from animal experiments that had indicated the relationship between the applied quantity of the drug and the resulting biological concentrations. Preliminary results of treatment with 0.5 ml Arteparon forte in 15 patients were reported.