The metabolic effects of 2-week fructose feeding in normal subjects

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Abstract
We studied the metabolic effects of 2 wk of fructose feeding as the sweetener in the diet of 11 normal individuals. The data demonstrated 1) no adverse effects of the fructose containing diet on triglyceride, pyruvate, lactate, or uric acid metabolism; 2) no apparent adaptation in the metabolism of fructose; 3) markedly flattened postprandial serum glucose and insulin responses to pure fructose; and 4) a modest decline in postprandial glucose and insulin levels after ingestion of standard fructose containing mixed meals as compared to sucrose-containing mixed meals.