Monoclonal antibody G 250 recognizes a determinant present in renal‐cell carcinoma and absent from normal kidney
- 15 October 1986
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 38 (4) , 489-494
- https://doi.org/10.1002/ijc.2910380406
Abstract
This report describes a monoclonal antibody designated G 250, subclass IgGI, that recognizes an antigen preferentially expressed on cell membranes of renalcell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium. G 250 antibody reacted with 46 of 47 primary RCC, with 7 of 8 RCC metastases and with a few other malignant tumors. The staining pattern of G 250 differs from that of other RCC-related antibodies described. Preliminary experiments show that this antibody can be used to visualize RCC xenografts in nude mice by immunoscintigraphy.This publication has 19 references indexed in Scilit:
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