INFLUENCE OF SUXAMETHONIUM ON THE POTENCY OF ORG NC 45 IN ANAESTHETIZED PATIENTS
Open Access
- 1 March 1981
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 53 (3) , 259-262
- https://doi.org/10.1093/bja/53.3.259
Abstract
The non-depolarizing neuromuscular block produced by Org NC45 was potentiated by the previous administration of suxamethonium 1 mg kg−1, shown by twitch depression of 91.3±2.4% when the same dose of Org NC 45 was administered after recovery from suxamethonium compared with the control value of 71.9±6.5%. The recovery index was also prolonged from 8.1±0.3 to 10.4±1.0min after suxamethonium. The dose-response curves for Org NC 45 showed a 1.66 potentiation factor for ED50 and 1.73 for ED9.5, caused by the previous administration of suxamethonium. This interaction is likely to occur in the plasma.Keywords
This publication has 3 references indexed in Scilit:
- RELATIVE POTENCY OF ORG NC 45, PANCURONIUM, ALCURONIUM AND TUBOCURARINE IN ANAESTHETIZED MANBritish Journal of Anaesthesia, 1980
- The Neuromuscular Blocking Action of ORG NC 45, A New Pancuronium Derivative, in Anaesthetized PatientsBritish Journal of Anaesthesia, 1980
- First Clinical Experiences with ORG NC 45British Journal of Anaesthesia, 1980