Factors influencing the occurrence of late bronchial reactions after allergen challenge
- 1 May 1990
- Vol. 45 (4) , 268-274
- https://doi.org/10.1111/j.1398-9995.1990.tb00495.x
Abstract
Forty-seven patients with allergic bronchial asthma were challenged with the relevant allergen. Forty-eight per cent of the provocations resulted in a positive immediate reaction followed by a late bronchial response. Late bronchial obstruction was more common among patients with a high than with a low RAST score. Ten patients were challenged with different allergens on two different occasions, but the same type of bronchial response was observed in only six of them. Nine patients with an isolated immediate response were rechallenged with higher allergen doses, the early bronchial response being partially counteracted by terbutaline inhalations in clinically appropriate doses before and during the inhalation of allergen. The treatment alleviated the early reaction in six of the patients. A late reaction occurred in all patients with an immediate response. The non-specific bronchial reactivity to methacholine was assessed in 24 patients before allergen challenge. No relation was found between this reactivity and the observed patterns of reactions to allergen. It was concluded that the occurrence of a late bronchial response probably depends on the dose of allergen administered but is independent of the degree of unspecific bronchial responsiveness to methacholine prior to the challenge.Keywords
This publication has 21 references indexed in Scilit:
- Allergen-induced nasal hyperreactivity appears unrelated to the size of the nasal and dermal immediate allergic reactionAllergy, 1987
- The temporal relationship between increases in airway responsiveness to histamine and late asthmatic responses induced by occupational agentsJournal of Allergy and Clinical Immunology, 1987
- Early and late allergic bronchial reactions: physiological characteristicsClinical and Experimental Allergy, 1986
- Sustained Inhibition of Antigen‐Induced Histamine Release from Human Lung by the β2‐Adrenoceptor Agonist TerbutalineAllergy, 1984
- Relationship between types of asthmatic reaction, nonspecific bronchial reactivity, and specific IgE antibodies in patients with red cedar asthmaJournal of Allergy and Clinical Immunology, 1983
- Significance of late reactions after bronchial challenge with house dust mite.Archives of Disease in Childhood, 1976
- The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.Journal of Clinical Investigation, 1976
- Factors which influence late cutaneous allergic responsesJournal of Allergy and Clinical Immunology, 1976
- Factors in allergen-induced asthma: relevance of the intensity of the airways allergic reaction and non-specific bronchial reactivityClinical and Experimental Allergy, 1976
- Late asthmatic responses induced by ragweed pollen allergenPublished by Elsevier ,1974