Angiokeratoma Corporis Diffusum Universale (Fabry's Disease) in Two Brothers

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Abstract
ANGIOKERATOMA corporis diffusum universale, or Fabry's disease, was regarded as a dcrmatologie curiosity until a description by Ruiter and Pompen1 from the Netherlands in 1939 suggested that it was a progressive systemic disorder. Since Fabry's2 original paper in 1898 about 35 cases have been described. The first case report in North America was published in 1955,3 and since then 4 more have been recorded.4 It is apparent from a review of the cases reported that a characteristic clinical pattern of progressive disease develops. At about the time of puberty in males, skin lesions that are only slowly progressive appear on . . .