Dose Response on the Faecal Colonisation of Lactobacillus Strain GG Administered in Two Different Formulations

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Abstract
Faecal concentrations of Lactobacillus GG in human subjects were studied after oral administration of the bacterium Lactobacillus GG was given in total to 44 healthy human volunteers for 7 d as enterocoated tablets with daily doses of 1 × 109c.f.u.,4x 109and 8 × 109 c.f.u. and in fermented milk with daily doses of 21 × 109c.f.u. and 1.2 × 1010 c.f.u. All the volunteers excreted the organism by day 3 of the test period. There were no statistical differences in mean faecal Lactobacillus GG contents between the tablet groups. With fermented milk there was a clear, statistically significant increase in mean faecal Lactobacillus GG content when the administration was l.2x 1010 c.f.u./d compared to 21 × 109 c.f.u./d. The results indicate that fermented milk and enterocoated tablets are good carriers for administering Lactobacillus GG as a probiotic organism