Synthesis and spasmolytic activity of aminoalkyl 2-substituted-2-(1,2-benzisoxazol-3-yl)acetates.

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Abstract
Several aminoalkyl esters of 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetic acid, 1-(1,2-benzisoxazol-3-yl)-1-cyclopentanecarboxylic acid, and 1-(1,2-benzisoxazol-3-yl)-1-cyclohexanecarboxylic acid and their quaternary ammonium salts were synthesized. The anticholinergic (anti-Ach) and musculotropic (anti-KCl) activities of these compounds were examined. Among them, 3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate (8b) showed potent anti-Ach and anti-KCl activities.

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