The Analgesic Effect of Dromoran Hydrobromide (3-hydroxy-N-methyl Morphinan Hydrobromide) in Postoperative Pain

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Abstract
A new synthetic morphine analogue, Dromoran Hydrobromide, § has recently been introduced into clinical medicine. The chemical formula of Dromoran Hydrobromide is 3-hydroxy-N-methyl morphinan hydrobromide. For the sake of brevity, the compound will be referred to hereinafter as "Dromoran." It was synthesized by Schnider and Grüssner1 in the laboratories of the Hoffmann–La Roche Company in Switzerland, and its pharmacologic properties were studied by Randall and Lehmann.2 The analgesic effect of Dromoran in man was studied by Junkerman, Heen and Pohle,3 Tidrick and others,4 Gross and others,5 Zager and others6 and Curreri, Gale and Dickie.7 Zager and others6 and Lee and Hasegawa . . .

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