LYMPHOID INFILTRATION IN THE F1 HYBRID LIVER AS A THYMUS CELL FUNCTION

Publisher Website
Google Scholar
Abstract
SUMMARY Parental lymph node and spleen cells are highly potent in the capacity to produce para vascular lymphocytic infiltrates (PVI) in the livers of F1 hybrids. Specific preimmunization of the donors augments this capacity. Thymus cells have no significant PVI-producing ability. On the other hand, thymus cells, despite their limited proliferative capacity, restore to lethally irradiated parental strain mice the ability of their spleen cell suspensions to produce PVI in F1 hybrid hosts. Bone marrow cells exhibit no significant PVI-producing capacity. Despite their marked proliferative capacity, bone marrow cells do not, within a 7-day period, restore to lethally irradiated syngeneic mice the capacity of their spleen cell suspensions to produce PVI upon injection into F1 hybrid recipients. Bone marrow cells, when administered in combination with thymus cells, do not augment the capacity of the latter to restore to lethally irradiated mice the ability of their spleen cell suspensions to produce PVI in F1 hybrid recipients. The PVI-producing thymus cells merely become diluted in the host spleen among the more rapidly proliferating donor bone marrow cells.

This publication has 0 references indexed in Scilit: