ORIGIN OF BONE-MARROW STROMAL MECHANOCYTES IN RADIOCHIMERAS AND HETEROTOPIC TRANSPLANTS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 6  (5) , 440-444
Abstract
Strain histocompatibility antigens (detected by indirect immunofluorescence reaction) and sex chromosomes were used as markers of donor and recipient cells in monolayer cultures of bone marrow from radiochimeras and from heterotopic transplants. In contrast to macrophages and hemopoietic cells, all bone marrow fibroblast precursors in radiochimeras were of recipient origin; in heterotopic transplants they were of donor origin. These data point to the decisive role of stromal mechanocytes, and not macrophages or hemopoietic cells, in creating the bone marrow hematopoietic microenvironment.