On the Influence of a Monolateral Carotid Ligation Upon the Formation of Radiation Cataract in Rats (With Colour Plate I)

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Abstract
In a first experiment, it could be shown with the particle distribution method that a monolateral carotid ligature in rats reduces ocular blood flow on the affected side for a period of at least 1–2 weeks. In a second experiment, the effect of a carotid ligation on the development of X-ray cataracts was studied in female white Wistar rats by slit-lamp follow-up. The test period was 200 days. If rats that had been irradiated with 440 R were submitted to a ligature of the right common carotid 38 days after irradiation, the development of lens opacities was accelerated and more pronounced on the ligated side. In another group ligated 15 days after X-ray exposure this behaviour was less pronounced. Wet weight of irradiated lenses was reduced. A carotid ligature alone did not affect lens weight. After a combined treatment with X-rays and a monolateral carotid ligation, however, the lenses on the ligated side were considerably lighter.

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