Effect of morphine and its conjugates on the isolated ileal preparation of guinea-pig.

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Abstract
The inhibitory effect of morphine and its 3 pairs of 3- and 6-conjugates (glucuronides, ethereal sulfates and phosphates) to nicotine-induced contraction of the isolated guinea-pig ileum was examined to establish that morphine-6-conjugates cause potent analgesia by themselves in mice. The potency of these conjugates decreased in the following order, morphine-6-sulfate > morphine-6-glucuronide > morphine, morphine-3- and 6-phosphate > morphine-3-glucuronide, morphine-3-sulfate, indicating fairly good accordance with order in their analgesic effects in mice. The observed biological effects were apparently attributable to the conjugates themselves.

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