Effect of cloned interferon‐γ on expression of H‐2 and Ia antigens on cell lines of hemopoietic, lymphoid, epithelial, fibroblastic and neuronal origin

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Abstract
Interferon‐γ (IFN‐γ), tested in the form of the product of a cloned murine IFN‐γ gene, was found to increase the expression of H‐2 antigens on cultured cell lines of a wide variety of cell types including factor‐dependent hemopoietic cells, pre‐B and B cells, macrophages, T cells, mast cells and cell lines of epithelial, fibroblastic and neuronal origin. However, IFN‐γ induced Ia antigens on only B cells, macrophages and T‐dependent mast cells or persisting cells. On the basis of these results, we suggest that a major function of IFN‐γ is to potentiate immune responses by enhancing the expression of H‐2 and Ia antigens on a variety of cell types.
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