STUDIES OF THE ORIGIN OF PLATELET-ASSOCIATED FIBRINOGEN

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 104  (2) , 223-237
Abstract
Platelet membranes and whole platelet preparations were examined by crossed immunoelectrophoresis in normal individuals, in a patient with congenital afibrinogenemia, and in 2 unrelated patients with Glanzmann''s thrombasthenia (types I and II) to study the origin of platelet-associated fibrinogen. Platelet and plasma fibrinogen are probably derived from the same gene product, platelet fibrinogen is not derived from the surrounding plasma milieu, under basal conditions, platelet fibrinogen is located only within the .alpha.-granules and not on the platelet surface, addition of trypsin to fibrinogen uncovers either a neoantigen or a hidden pool of platelet fibrinogen in the .alpha.-granules, platelets from 2 patients with Glanzmann''s thrombasthenia contain near-normal quantities of fibrinogen.